Lock, Stock and Two Smoking Barrels

Long-time friends and small-time London criminals Eddie, Tom, Soap, and Bacon put together £100,000 so that Eddie, a card sharp, can participate in one of "Hatchet" Harry Lonsdale's high-stakes three-card brag games. The game, however, is rigged, and they wind up owing £500,000 to Harry, to be paid within a week. Harry sends his debt collector, Big Chris, to Eddie's father, JD, since Harry's true intention is to acquire JD's bar in payment of the debt.

Also interested in two expensive antique Holland & Holland shotguns up for auction, Harry gets his enforcer, Barry "the Baptist," to hire two thieves, Gary and Dean, to steal them from a bankrupt lord. After the incompetent thieves unwittingly sell them to Nick "the Greek,"  a local fence, Barry threatens them into retrieving the guns. Meanwhile, Eddie returns home and overhears his neighbours, a gang of robbers led by a brutal man called Dog," planning a heist on some cannabis growers loaded with cash and drugs. He tells the other three and they decide to rob the neighbours after they return from their heist. Tom buys the shotguns from Nick (both unaware of their true value), for use in the plan.

Dog's gang executes their heist, and despite a gang member's death by his own Bren gun and an incriminating encounter with a traffic warden, they succeed, returning with a duffel bag full of money and a van loaded with bags of cannabis. Eddie and his friends ambush them and escape in the van containing the cannabis and the warden. They transfer the loot to their own van and return home, knocking out the warden and dumping him by the road before arranging for Nick to fence the drugs to violent gangster Rory Breaker. Rory agrees to buy the cannabis at half price but two of his men visit the house of the growers, discover that they have been robbed and the cannabis he just bought has been stolen from his own growers. Rory threatens Nick into giving him Eddie's address and tasks one of the growers, Winston, to identify the robbers.

While the friends celebrate at JD's bar, Dog's crew, having accidentally discovered that they were robbed by their neighbours, set up an ambush in Eddie's flat. Rory and his gang arrive at the flat instead and in the ensuing shoot-out, all except Dog and Winston are killed. Winston leaves with the drugs. Dog attempts to escape with the shotguns and the cash, but Big Chris arrives, incapacitates him, and takes both. Attempting to recover the guns, Gary and Dean follow Chris, oblivious to the fact that Chris is bringing them to Harry.

Having delivered the money and guns to Harry, Chris returns to his car to find Dog holding his son Little Chris at knifepoint, demanding the cash be returned to him. Chris complies and starts the car. Meanwhile, Gary and Dean burst into Harry's office. The ensuing confrontation results in the deaths of Gary, Dean, Barry and Harry. Having discovered the carnage at their flat and their loot missing, the four friends head to Harry's office, finding a second set of corpses, and decide to take the money for themselves. Chris deliberately crashes into their car to disable Dog and then fatally bludgeons him with his car door. He then retrieves the cash from the unconscious Eddie but allows Tom to leave with the shotguns after a brief stand-off.

The friends are arrested but soon acquitted after the warden identifies Dog and his crew as the culprits. Back at the bar, Eddie, Bacon and Soap dispatch Tom to discard the guns, as they are the only remaining evidence linking them to the case. Chris then arrives to return the bag, from which he has taken all the cash for himself and his son and which now contains a catalogue of antique weapons. Leafing through the catalogue, the three friends learn that the shotguns are actually far more valuable than they had realised and frantically call Tom to dissuade him from disposing of them. The film ends with Tom leaning over Southwark Bridge, holding his mobile phone ringing in his mouth, as he prepares to drop the guns into the River Thames.